Breast, Synovial-type Metaplasia [LMP98699]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
Diagnosis: 
Synovial-type metaplasia
Species: 
Human
Organ System: 
Breast
Gender: 
Female
Age: 
43 years
Diagnosis Code: 
ICD-10: N61
Slide Contributor Information
Elzbieta
Slodkowska

Keywords

Papillary synovial metaplasia

Clinical History

Breast tissue expanders

Clinical Discussion

The presence of a foreign body can result in reactive changes within the surrounding connective tissue. One such reaction is synovial-type metaplasia, in which the tissue in contact with a breast expander or implant transforms into a lining similar to a joint space. Rarely, it can be florid as in this case. The cells are similar immunohistochemically to true synovial cells (CD68 positive, cytokeratin negative).