Liver, Alcoholic steatohepatitis [LMP40116]

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Diagnostic Modality: 
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Disease Category: 
Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
Diagnosis: 
Alcoholic steatohepatitis
Species: 
Human
Organ System: 
Liver and Biliary Tract
Gender: 
Male
Age: 
35 years
Diagnosis Code: 
ICD-10: K70.9
Slide Contributor Information
Forse, C., Latta, E.

Keywords

alcoholic liver disease

Clinical History

Transjugular liver biopsy.

Clinical Discussion

Steatohepatitis is characterized by the combination of hepatocyte injury, inflammation, steatosis and fibrosis. Required histological findings include the presence of macrovesicular steatosis (large droplets of fat within hepatocytes that push the nuclei to the periphery) with evidence of hepatocyte damage (hepatocyte ballooning, lobular inflammation with neutrophil predominance, Mallory-Denk bodies, megamitochondria, and fibrosis (most often pericellular and sinusoidal).

Note that alcoholic steatohepatitis is indistinguishable histologically from nonalcoholic steatohepatitis (NASH). Clinical history is required to definitively distinguish between these two entities.