Lymph nodes, Kikuchi-Fujimoto Lymphadenitis, CD68 stain [LMP64026]
Keywords
histiocytic necrotizing lymphadenitis, Kikuchi-Fujimoto, Kikuchi disease
Clinical History
Previously healthy 13 year old boy with two month history of cervical lymphadenopathy, and two week history of fevers, night sweats, fatigue and weight loss.
Clinical Discussion
Kikuchi-Fujimoto disease (KFD) is an acute, self-limited, lymphadenopathy affecting young patients, with cervical lymph nodes most commonly affected. Patients usually present with B-type symptoms and cervical lymphadenopathy. The etiology is unclear, however viral (EBV, HHV6) or autoimmune causes have been suggested.
There are three phases of KFD: lymphohistiocytic/proliferative, necrotic and phagocytic/foamy cell type.
Lymphoma, systemic lupus erythematosus, viral and bacterial infections, and Kawasaki disease need to be considered and ruled out.
This slide shows CD68 stain. See Related Content for H&E and CD3 stains.
There are three phases of KFD: lymphohistiocytic/proliferative, necrotic and phagocytic/foamy cell type.
Lymphoma, systemic lupus erythematosus, viral and bacterial infections, and Kawasaki disease need to be considered and ruled out.
This slide shows CD68 stain. See Related Content for H&E and CD3 stains.
Related Content
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