Oral cavity, ligneous gingivitis [LMP27443]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
Diagnosis: 
Ligneous gingivitis
Species: 
Human
Organ System: 
Head and Neck
Gender: 
Male
Age: 
11 years
Diagnosis Code: 
ICD-10: K05.1
Slide Contributor Information
Cassol, C., Somers, G.

Keywords

gingiva, gingival, dental, oral, plasminogen deficiency, hypoplasminogenemia, gingival hyperplasia, fibrin, conjunctivitis

Clinical History

11-year-old male with hyperplastic gingiva with white-yellow plaques. Family history of ligneous conjunctivitis.

Clinical Discussion

The gingival biopsy shows subepithelial accumulation of amorphous eosinophilic material that is PAS positive-diastase resistant and stains purple-red on picro-Mallory stain, confirming the material is fibrin in nature. Ulceration and secondary bacterial colonization are also present. The morphology is consistent with ligneous gingivitis, a condition associated with ligneous conjunctivitis, which is seen in patients with hypoplasminogenemia. The condition is triggered by local injury, trauma or infection and involves mucosal sites. It can be sporadic or familial with autosomal recessive transmission.

Related Content

Related External Links: 
Destructive Membranous Periodontal Disease (Ligneous Gingivitis): A Literature Review