Placenta, villitis of unknown etiology [LMP71668]

LMP71668 thumbnail
View the Zoomify Image
Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Acute and Chronic Inflammation
Diagnosis: 
Villitis of unknown etiology
Species: 
Human
Organ System: 
Female Genital Tract
Gender: 
Female
Age: 
36 years
Diagnosis Code: 
ICD-10: O43.9
Slide Contributor Information
Chang, M.

Keywords

Chronic villitis

Clinical History

Placental examination after delivery of a term infant.

Clinical Discussion

Villitis of unknown etiology (VUE) is a chronic inflammation of the chorionic villi that is seen both incidentally and in association with intrauterine growth restriction, premature labour, and recurrent stillbirths. The main diagnostic feature is the presence of lymphocytes and macrophages within the villous stroma. Avascular villi and perivillous fibrin are also commonly seen. No pathogenic organisms are identified, and VUE is thought to result from a maternal immune response.