Skin, Trichilemmal cyst [LMP73399]

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Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
Diagnosis: 
Trichilemmal cyst
Species: 
Human
Organ System: 
Skin
Gender: 
Female
Age: 
45 years
Diagnosis Code: 
ICD-10: L72.1
Slide Contributor Information
Kanaroglou, S., Latta, E.

Keywords

skin, cyst, trichilemmal, pilar

Clinical History

Skin lesion from scalp.

Clinical Discussion

Trichilemmal cysts are the second most common type of cutaneous cyst and occurs on the scalp up to 90% of the time. They tend to occur in adults and can be treated with simple excision. Typically, and in this case, the microscopic appearance is that of a circumscribed simple cyst filled with dense eosinophilic keratin. The epithelium is stratified squamous epithelium lacking a granular layer. Large polygonal keratinocytes with abrupt keratinization are present. Calcification can be present in 25% of cases and is present in this case. Also, trichilemmal cysts may rupture and generate a granulomatous response. In this case, the cyst has ruptured and there are foci of multinucleate giant cells.

See related content for references:

1) Leppard, BJ., et al. Br J Dermatol. 1976 Apr;94(4):379-90.
2) Tellechea, O., et al. An Bras Dermatol. 2015 Nov-Dec;90(6):780-96

Related Content

Related External Links: 
Leppard, BJ., et al. The natural history of trichilemmal cysts. Br J Dermatol. 1976 Apr;94(4):379-90.
Tellechea, O., et al. Benign follicular tumors. An Bras Dermatol. 2015 Nov-Dec;90(6):780-96