Soft Tissue, Fibrous hamartoma of infancy [LMP39304]

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Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Diseases of Infancy and Childhood
Diagnosis: 
Fibrous hamartoma of infancy
Species: 
Human
Organ System: 
Bones, Joints, and Soft-Tissue Tumours
Gender: 
Male
Age: 
11 months
Diagnosis Code: 
ICD-10: D21.9
Slide Contributor Information
Cassol, C., Somers, G.

Keywords

infant, soft tissue, triphasic

Clinical History

11-month-old male with gradually enlarging nodule on the left arm since 4 months of age. Nodule is hard, mobile and not fixed.

Clinical Discussion

Fibrous hamartoma of infancy is a benign superficial soft tissue tumour that usually presents in the first 2 years of life with 20% presenting at birth. There is a male predominance. Most common sites of involvement include the axillary and inguinal regions, upper arms, trunk and external genitalia. Grossly, these lesions are poorly demarcated. Microscopically, they exhibit a characteristic organoid pattern with 3 components: 1) bands of mature fibrous tissue; 2) nests of immature myxoid or basophilic mesenchyme with primitive ovoid, spindle or stellate cells; and 3) interspersed mature adipose tissue. Treatment is with surgical excision. There is a 15% recurrence rate (probably due to incomplete resection) which can be cured by re-excision.