Colon, collagenous colitis [LMP30197]

LMP30197 Thumbnail
View the Zoomify Image
Image Details
Diagnostic Modality: 
Whole Slide Image
Disease Category: 
Acute and Chronic Inflammation
Diagnosis: 
Collagenous colitis
Species: 
Human
Organ System: 
Gastrointestinal Tract
Gender: 
Male
Age: 
68 years
Diagnosis Code: 
ICD-10: K52.8
Slide Contributor Information
Yoon, J., Hafezi-Bakhtiari, S.

Keywords

microscopic colitis, collagenous colitis

Clinical History

68-year old male with watery diarrhoea and no endoscopic lesions.

Clinical Discussion

Collagenous colitis is a pattern of microscopic colitis: inflammation of the colon with no endoscopic findings. There are two main patterns of microscopic colitis: lymphocytic and collagenous. While both types show increased intra-epithelial lymphocytes (although fewer than seen in lymphocytic colitis) and mucin depletion, collagenous colitis is notable for patchy thickening of the sub-epithelial basement (10 microns or more, usually at least 15-20 micron-thick).